Neurobiology: Dopamine receptor disputes

The D3 dopamine receptor: neurobiology and potential clinical relevance.

Neurobiology of dopamine in schizophrenia.

This chapter is an update on the dopamine (DA) imbalance in schizophrenia, including the evidence for subcortical hyperstimulation of D2 receptors underlying positive symptoms and cortical hypodopaminergia-mediating cognitive disturbances and negative symptoms. After a brief review of the anatomical neurocircuitry of this transmitter system as a background, we summarize the evidence for dopamin...

The neurobiology of dopamine signaling.

The brain contains 2 major groups of dopamine neurons. One is located in the arcuate nucleus of the hypothalamic median eminence and is involved in neuroendocrine regulation. The other, which is the subject of this article, is located in the ventral mesencephalon and projects to the forebrain. Although dopamine neurons are few (<1/100 000 brain neurons), they play an important role in regulatin...

P139: Role of Dopamine Receptor D3 in Depression and Anxiety

Dopamine (DA) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. The dopaminergic system is the primary therapeutic target in the treatment of Parkinson’s disease (PD), drug addiction and schizophrenia. Notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...

Neurobiology of Disease L-DOPA Impairs Proteasome Activity in Parkinsonism through D1 Dopamine Receptor

Amandine Berthet,1 Erwan Bezard,1,2 Gregory Porras,1 Stefania Fasano,3 Pedro Barroso-Chinea,1 Benjamin Dehay,1 Audrey Martinez,1 Marie-Laure Thiolat,1 Marika Nosten-Bertrand,4 Bruno Giros,4 Jérôme Baufreton,1 Qin Li,2 Bertrand Bloch,1 and Marie-Laure Martin-Negrier1 1Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Institute of Neurodegenerative Diseases, 3307...